Prescription Weight-loss Medications

For some patients, lifestyle changes such as diet, physical activity, and behavior may not produce enough weight loss to improve health. Patients with a BMI greater than 30.0, or a BMI greater than 27.0 with other obesity-associated conditions, are often prescribed weight-loss medications to take in addition to making lifestyle changes. Reducing calorie intake and increasing physical activity remain an essential part of treatment for obesity, even for patients who are prescribed weight-loss medications.

Orlistat
Orlistat is a drug that blocks some fat from food and prevents it from being absorbed by the body. It can be effective for weight loss when used in combination with a reduced-calorie diet for six months to one year. Orlistat can also be used to help maintain a healthy weight after weight loss.

Lorcaserin
Lorcaserin is a drug that affects the chemicals in the brain that control appetite. Used with a reduced-calorie diet and increased physical activity, lorcaserin is often prescribed to treat obesity that is related to diabetes, high cholesterol, or high blood pressure. Lorcaserin can also be used to help maintain a healthy weight after weight loss.

Phentermine/Topiramate Extended-Release (P/T ER)
Phentermine/topiramate extended-release is a combination of two drugs used to control appetite. P/T ER should be used in combination with increased physical activity, a reduced-calorie diet, and other behavioral strategies. It can also be used to help maintain a healthy weight after weight loss.